How eCFR Flags an Unincorporated Amendment in 21 CFR §1308.11

When you open 21 CFR §1308.11 (the Schedule I list of controlled substances) on eCFR, the codified text on the page is not necessarily the most current legal state of that section. eCFR flags this with a single one-line cross-reference note that sits directly above the section text: “Link to an amendment published at 90 FR 57542, Dec. 11, 2025.” (eCFR §1308.11). That note is a live, resolvable link. Clicking it (or navigating to the Federal Register citation it names) takes you to the actual amending document, which in this case is a temporary scheduling order for the substance CUMYL-PEGACLONE. As of the check that produced this article, that one-line note was the only cross-reference note appearing anywhere in Part 1308 — it appeared exactly once, at §1308.11.

This original record-reading guide is a general reading aid, not cited evidence. It does not depict a source record; the article text and source links provide the facts.

Key points

• eCFR marks an unincorporated amendment with one line above the section text: “Link to an amendment published at 90 FR 57542, Dec. 11, 2025.” (eCFR §1308.11)
• At the time checked, this note appeared exactly once across all of Part 1308, and it appeared at §1308.11.
• The note links to a specific, dated Federal Register document titled “Schedules of Controlled Substances: Extension of Temporary Placement of CUMYL-PEGACLONE in Schedule I of the Controlled Substances Act” (Federal Register, 2025-22496).
• That document is itself a temporary order with its own effective and expiration dates, not a permanent change.

eCFR Note

If you land on §1308.11 directly, look for the line above the section heading and text. It reads: “Link to an amendment published at 90 FR 57542, Dec. 11, 2025.” (eCFR §1308.11). This is eCFR’s way of telling a reader that a rule affecting this section has been published in the Federal Register but has not yet been merged into the codified text displayed below the note. Nothing else on the §1308.11 page states this in prose — it is this single line, and it is the mechanism to check for on any eCFR section page when you want to know whether the displayed text is current.

Where the note points

Following the citation named in the note — 90 FR 57542, published December 11, 2025 — leads to a Federal Register document titled “Schedules of Controlled Substances: Extension of Temporary Placement of CUMYL-PEGACLONE in Schedule I of the Controlled Substances Act” (Federal Register, 2025-22496). The Federal Register’s own metadata for this document lists an “Effective Date” of “2025-12-12” (Federal Register, 2025-22496).

Document Duration

The document is explicit about being time-limited rather than permanent. Its own text states: “This temporary scheduling order, which extends schedule I control of CUMYL-PEGACLONE covered by an order (88 FR 86040, December 12, 2023), is effective December 12, 2025, and expires on December 12, 2026. If DEA publishes a final rule making this scheduling action permanent, this order will expire on the effective date of that rule, if the effective date is earlier than December 12, 2026.” (Federal Register, 2025-22496). In other words, the document that the eCFR note points you to describes its own effective window and the specific condition under which that window would end early.

Reading eCFR

The takeaway is procedural, not substantive: a one-line cross-reference note above a section’s text on eCFR is the signal that a Federal Register document exists which affects that section but has not yet been folded into the displayed codified language. The note names the exact citation and date of that document, and following it is how a reader gets to the authoritative, currently governing text rather than relying on the codified display alone. This pattern held for all of Part 1308 at the time this was checked — one note, at one section, pointing to one document.

What this article does not answer

This article does not state or characterize the current schedule status of CUMYL-PEGACLONE or of any other substance in Part 1308; determining that requires opening and reading the linked Federal Register document yourself, since a schedule status can be time-limited or subject to further action. It does not describe any medical, legal, or enforcement consequence that a schedule placement might have for any person. And it does not say whether the pending amendment described in eCFR’s cross-reference note will ultimately be made permanent, extended again beyond December 12, 2026, or allowed to lapse — the linked document states only its own effective and expiration terms as of its publication, not a future outcome.

Source records

https://www.ecfr.gov/current/title-21/chapter-II/part-1308/section-1308.11 https://www.federalregister.gov/documents/2025/12/11/2025-22496/schedules-of-controlled-substances-extension-of-temporary-placement-of-cumyl-pegaclone-in-schedule-i